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June 22, 2009
Polyphenon E May Affect Prostate Cancer Progression
According to results of a study published
in Cancer Prevention Research,
a journal of the American Association for Cancer Research (AACR),
men with prostate cancer who took the investigational catechin
compound Polyphenon E demonstrated a significant reduction in
serum markers predictive of prostate cancer progression. The
study was conducted by James A. Cardelli and his research
colleagues at the Feist-Weiller Cancer Center at Louisiana State
University (LSU) Health Sciences Center-Shreveport to
determine the effects of short-term supplementation with green
tea’s active compounds on serum biomarkers in patients with
prostate cancer. It included 26 men, 41
to 72 years old, who had prostate cancer and were scheduled for
radical prostatectomy. The men took four capsules a day of
Polyphenon E for 12 to 73 days, with a median time of 34.5 days,
but stopped the day before surgery.
The LSU study found "significant" reductions in serum markers
predictive of prostate cancer progression, including hepatocyte
growth factor, vascular endothelial growth factor and prostate
specific antigen. In some men, reductions in levels of these
markers were greater than 30 percent, the researchers found.
There were few reported side effects, and the men's liver
function remained normal.
For more information, see the AACR news release.
http://www.aacr.org/home/public--media/aacr-press-releases.aspx?d=1409
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